Probing the SELEX Process with Next-Generation Sequencing

BACKGROUND: SELEX is an iterative process in which highly diverse synthetic nucleic acid libraries are selected over many rounds to finally identify aptamers with desired properties. However, little is understood as how binders are enriched during the selection course. Next-generation sequencing off...

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Bibliografiske detaljer
Main Authors: Schütze, Tatjana, Wilhelm, Barbara, Greiner, Nicole, Braun, Hannsjörg, Peter, Franziska, Mörl, Mario, Erdmann, Volker A., Lehrach, Hans, Konthur, Zoltán, Menger, Marcus, Arndt, Peter F., Glökler, Jörn
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248438/
https://ncbi.nlm.nih.gov/pubmed/22242135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029604
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