Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

Glioblastoma multiforme (GBM) is the most common and lethal of all gliomas. The current standard of care includes surgery followed by concomitant radiation and chemotherapy with the DNA alkylating agent temozolomide (TMZ). O(6)-methylguanine–DNA methyltransferase (MGMT) repairs the most cytotoxic of...

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Bibliografski detalji
Glavni autori: Agnihotri, Sameer, Gajadhar, Aaron S., Ternamian, Christian, Gorlia, Thierry, Diefes, Kristin L., Mischel, Paul S., Kelly, Joanna, McGown, Gail, Thorncroft, Mary, Carlson, Brett L., Sarkaria, Jann N., Margison, Geoffrey P., Aldape, Kenneth, Hawkins, Cynthia, Hegi, Monika, Guha, Abhijit
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2011
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248301/
https://ncbi.nlm.nih.gov/pubmed/22156195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59334
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