Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

Glioblastoma multiforme (GBM) is the most common and lethal of all gliomas. The current standard of care includes surgery followed by concomitant radiation and chemotherapy with the DNA alkylating agent temozolomide (TMZ). O(6)-methylguanine–DNA methyltransferase (MGMT) repairs the most cytotoxic of...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Agnihotri, Sameer, Gajadhar, Aaron S., Ternamian, Christian, Gorlia, Thierry, Diefes, Kristin L., Mischel, Paul S., Kelly, Joanna, McGown, Gail, Thorncroft, Mary, Carlson, Brett L., Sarkaria, Jann N., Margison, Geoffrey P., Aldape, Kenneth, Hawkins, Cynthia, Hegi, Monika, Guha, Abhijit
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248301/
https://ncbi.nlm.nih.gov/pubmed/22156195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59334
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker