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Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR
Oncogenic Ras and p53 loss-of-function mutations are common in many advanced sporadic malignancies and together predict a limited responsiveness to conventional chemotherapy. Notably, studies in cultured cells have indicated that each of these genetic alterations creates a selective sensitivity to a...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248295/ https://ncbi.nlm.nih.gov/pubmed/22133876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58928 |
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