Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

Previous studies indicate that oncogenic stress activates the ATR-Chk1 pathway. Here, we demonstrate that ATR-Chk1 pathway engagement is essential for limiting genomic instability following oncogenic Ras transformation. ATR pathway inhibition in combination with oncogenic Ras expression synergistica...

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Detalhes bibliográficos
Main Authors: Gilad, Oren, Nabet, Barzin Y., Ragland, Ryan L., Schoppy, David W., Smith, Kevin D., Durham, Amy C., Brown, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057927/
https://ncbi.nlm.nih.gov/pubmed/21098704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2286
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