Creatine kinase–mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved

ATP is required for normal cardiac contractile function, and it has long been hypothesized that reduced energy delivery contributes to the contractile dysfunction of heart failure (HF). Despite experimental and clinical HF data showing reduced metabolism through cardiac creatine kinase (CK), the maj...

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Hauptverfasser: Gupta, Ashish, Akki, Ashwin, Wang, Yibin, Leppo, Michelle K., Chacko, V.P., Foster, D. Brian, Caceres, Viviane, Shi, Sa, Kirk, Jonathan A., Su, Jason, Lai, Shenghan, Paolocci, Nazareno, Steenbergen, Charles, Gerstenblith, Gary, Weiss, Robert G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248286/
https://ncbi.nlm.nih.gov/pubmed/22201686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57426
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