Tetramerization Dynamics of C-terminal Domain Underlies Isoform-specific cAMP Gating in Hyperpolarization-activated Cyclic Nucleotide-gated Channels

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are dually activated by hyperpolarization and binding of cAMP to their cyclic nucleotide binding domain (CNBD). HCN isoforms respond differently to cAMP; binding of cAMP shifts activation of HCN2 and HCN4 by 17 mV but shifts that of...

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Detalhes bibliográficos
Main Authors: Lolicato, Marco, Nardini, Marco, Gazzarrini, Sabrina, Möller, Stefan, Bertinetti, Daniela, Herberg, Friedrich W., Bolognesi, Martino, Martin, Holger, Fasolini, Marina, Bertrand, Jay A., Arrigoni, Cristina, Thiel, Gerhard, Moroni, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247997/
https://ncbi.nlm.nih.gov/pubmed/22006928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.297606
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