Hypoxia-induced Acidosis Uncouples the STIM-Orai Calcium Signaling Complex

The endoplasmic reticulum Ca(2+)-sensing STIM proteins mediate Ca(2+) entry signals by coupling to activate plasma membrane Orai channels. We reveal that STIM-Orai coupling is rapidly blocked by hypoxia and the ensuing decrease in cytosolic pH. In smooth muscle cells or HEK293 cells coexpressing STI...

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Detalles Bibliográficos
Autores principales: Mancarella, Salvatore, Wang, Youjun, Deng, Xiaoxiang, Landesberg, Gavin, Scalia, Rosario, Panettieri, Reynold A., Mallilankaraman, Karthik, Tang, Xiang D., Madesh, Muniswamy, Gill, Donald L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247972/
https://ncbi.nlm.nih.gov/pubmed/22084246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.303081
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