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Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts

Endogenous glucocorticoids (GCs) and inflammatory cytokines contribute to the age-associated loss of bone mass and strength, but the molecular mechanisms responsible for their deleterious effects on the aging skeleton are unclear. Based on evidence that oxidative stress is a causal mechanism of the...

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Detalles Bibliográficos
Main Authors: Almeida, Maria, Han, Li, Ambrogini, Elena, Weinstein, Robert S., Manolagas, Stavros C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247937/
https://ncbi.nlm.nih.gov/pubmed/22030390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.283481
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