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Oxidative Stress Stimulates Apoptosis and Activates NF-κB in Osteoblastic Cells via a PKCβ/p66(shc) Signaling Cascade: Counter Regulation by Estrogens or Androgens

Aging or acute loss of estrogens or androgens increases the levels of reactive oxygen species, activates nuclear factor-κB (NF-κB), and promotes the phosphorylation of p66(shc), a redox enzyme that amplifies mitochondrial reactive oxygen species generation and stimulates apoptosis. We report that in...

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Detalhes bibliográficos
Main Authors: Almeida, Maria, Han, Li, Ambrogini, Elena, Bartell, Shoshana M., Manolagas, Stavros C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954638/
https://ncbi.nlm.nih.gov/pubmed/20685851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0189
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