Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo

Glucocorticoid-induced osteoporosis is a frequent complication of systemic glucocorticoid (GC) therapy and mainly characterized by suppressed osteoblast activity. Wnt16 derived from osteogenic cells is a key determinant of bone mass. Here, we assessed whether GC suppress bone formation via inhibitin...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Hildebrandt, Susanne, Baschant, Ulrike, Thiele, Sylvia, Tuckermann, Jan, Hofbauer, Lorenz C., Rauner, Martina
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992207/
https://ncbi.nlm.nih.gov/pubmed/29880826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26300-z
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