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Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors

Iron overload due to hemochromatosis or chronic blood transfusions has been associated with the development of osteoporosis. However, the impact of changes in iron homeostasis on osteoblast functions and the underlying mechanisms are poorly defined. Since Wnt signaling is a critical regulator of bon...

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Publicat a:Haematologica
Autors principals: Baschant, Ulrike, Rauner, Martina, Balaian, Ekaterina, Weidner, Heike, Roetto, Antonella, Platzbecker, Uwe, Hofbauer, Lorenz C.
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479606/
https://ncbi.nlm.nih.gov/pubmed/27540134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.144808
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