Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers. Upon activation of the allosteric switch, there is a shift in helix 3/loop 7 associated with a disorder to order transition in the a...

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Autori principali: Buhrman, Greg, O’Connor, Casey, Zerbe, Brandon, Kearney, Bradley M., Napoleon, Raeanne, Kovrigina, Elizaveta A., Vajda, Sandor, Kozakov, Dima, Kovrigin, Evgenii L., Mattos, Carla
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247908/
https://ncbi.nlm.nih.gov/pubmed/21945529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.09.011
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