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Analysis of Binding Site Hot Spots on the Surface of Ras GTPase
We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers. Upon activation of the allosteric switch, there is a shift in helix 3/loop 7 associated with a disorder to order transition in the a...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3247908/ https://ncbi.nlm.nih.gov/pubmed/21945529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.09.011 |
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