BRCA1 is an essential regulator of heart function and survival following myocardial infarction

The tumour suppressor BRCA1 is mutated in familial breast and ovarian cancer but its role in protecting other tissues from DNA damage has not been explored. Here we show a new role for BRCA1 as a gatekeeper of cardiac function and survival. In mice, loss of BRCA1 in cardiomyocytes results in adverse...

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Detalhes bibliográficos
Main Authors: Shukla, Praphulla C., Singh, Krishna K., Quan, Adrian, Al-Omran, Mohammed, Teoh, Hwee, Lovren, Fina, Cao, Liu, Rovira, Ilsa I., Pan, Yi, Brezden-Masley, Christine, Yanagawa, Bobby, Gupta, Aanika, Deng, Chu-Xia, Coles, John G., Leong-Poi, Howard, Stanford, William L., Parker, Thomas G., Schneider, Michael D., Finkel, Toren, Verma, Subodh
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247816/
https://ncbi.nlm.nih.gov/pubmed/22186889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1601
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