BRCA2 Protein Deficiency Exaggerates Doxorubicin-induced Cardiomyocyte Apoptosis and Cardiac Failure

The tumor suppressor breast cancer susceptibility gene 2 (BRCA2) plays an important role in the repair of DNA damage, and loss of BRCA2 predisposes carriers to breast and ovarian cancers. Doxorubicin (DOX) remains the cornerstone of chemotherapy in such individuals. However, it is often associated w...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Singh, Krishna K., Shukla, Praphulla C., Quan, Adrian, Desjardins, Jean-François, Lovren, Fina, Pan, Yi, Garg, Vinay, Gosal, Sumandeep, Garg, Ankit, Szmitko, Paul E., Schneider, Michael D., Parker, Thomas G., Stanford, William L., Leong-Poi, Howard, Teoh, Hwee, Al-Omran, Mohammed, Verma, Subodh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325595/
https://ncbi.nlm.nih.gov/pubmed/22157755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292664
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados