BRCA2 Protein Deficiency Exaggerates Doxorubicin-induced Cardiomyocyte Apoptosis and Cardiac Failure

The tumor suppressor breast cancer susceptibility gene 2 (BRCA2) plays an important role in the repair of DNA damage, and loss of BRCA2 predisposes carriers to breast and ovarian cancers. Doxorubicin (DOX) remains the cornerstone of chemotherapy in such individuals. However, it is often associated w...

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Main Authors: Singh, Krishna K., Shukla, Praphulla C., Quan, Adrian, Desjardins, Jean-François, Lovren, Fina, Pan, Yi, Garg, Vinay, Gosal, Sumandeep, Garg, Ankit, Szmitko, Paul E., Schneider, Michael D., Parker, Thomas G., Stanford, William L., Leong-Poi, Howard, Teoh, Hwee, Al-Omran, Mohammed, Verma, Subodh
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325595/
https://ncbi.nlm.nih.gov/pubmed/22157755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292664
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