Toxicogenomics and Metabolomics of Pentamethylchromanol (PMCol)-Induced Hepatotoxicity

Pentamethyl-6-chromanol (PMCol), a chromanol-type compound related to vitamin E, was proposed as an anticancer agent with activity against androgen-dependent cancers. In repeat dose-toxicity studies in rats and dogs, PMCol caused hepatotoxicity, nephrotoxicity, and hematological effects. The objecti...

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Detalhes bibliográficos
Main Authors: Parman, Toufan, Bunin, Deborah I., Ng, Hanna H., McDunn, Jonathan E., Wulff, Jacob E., Wang, Abraham, Swezey, Robert, Rasay, Laura, Fairchild, David G., Kapetanovic, Izet M., Green, Carol E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Safety Evaluation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247806/
https://ncbi.nlm.nih.gov/pubmed/21920950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr238
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