Activation-Induced Cytidine Deaminase Expression in CD4(+) T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age

Activation-induced cytidine deaminase (AID), produced by the Aicda gene, is essential for the immunoglobulin gene (Ig) alterations that form immune memory. Using a Cre-mediated genetic system, we unexpectedly found CD4(+) T cells that had expressed Aicda (exAID cells) as well as B cells. ExAID cells...

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Detalhes bibliográficos
Main Authors: Qin, Hongyan, Suzuki, Keiichiro, Nakata, Mikiyo, Chikuma, Shunsuke, Izumi, Nakako, Thi Huong, Le, Maruya, Mikako, Fagarasan, Sidonia, Busslinger, Meinrad, Honjo, Tasuku, Nagaoka, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247255/
https://ncbi.nlm.nih.gov/pubmed/22216188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029141
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