Direct Observation of Defects and Increased Ion Permeability of a Membrane Induced by Structurally Disordered Cu/Zn-Superoxide Dismutase Aggregates

Interactions between protein aggregates and a cellular membrane have been strongly implicated in many protein conformational diseases. However, such interactions for the case of Cu/Zn superoxide dismutase (SOD1) protein, which is related to fatal neurodegenerative disorder amyotrophic lateral sclero...

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Main Authors: Choi, Inhee, Song, Hyeon Don, Lee, Suseung, Yang, Young In, Nam, Joo Hyun, Kim, Sung Joon, Sung, Jung-Joon, Kang, Taewook, Yi, Jongheop
格式: Artigo
語言:Inglês
出版: Public Library of Science 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247219/
https://ncbi.nlm.nih.gov/pubmed/22216152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028982
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