Thymidine Kinase 2 Deficiency-Induced Mitochondrial DNA Depletion Causes Abnormal Development of Adipose Tissues and Adipokine Levels in Mice

Mammal adipose tissues require mitochondrial activity for proper development and differentiation. The components of the mitochondrial respiratory chain/oxidative phosphorylation system (OXPHOS) are encoded by both mitochondrial and nuclear genomes. The maintenance of mitochondrial DNA (mtDNA) is a k...

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Autors principals: Villarroya, Joan, Dorado, Beatriz, Vilà, Maya R., Garcia-Arumí, Elena, Domingo, Pere, Giralt, Marta, Hirano, Michio, Villarroya, Francesc
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246498/
https://ncbi.nlm.nih.gov/pubmed/22216345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029691
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