Thymidine Kinase 2 Deficiency-Induced Mitochondrial DNA Depletion Causes Abnormal Development of Adipose Tissues and Adipokine Levels in Mice

Mammal adipose tissues require mitochondrial activity for proper development and differentiation. The components of the mitochondrial respiratory chain/oxidative phosphorylation system (OXPHOS) are encoded by both mitochondrial and nuclear genomes. The maintenance of mitochondrial DNA (mtDNA) is a k...

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Detalhes bibliográficos
Main Authors: Villarroya, Joan, Dorado, Beatriz, Vilà, Maya R., Garcia-Arumí, Elena, Domingo, Pere, Giralt, Marta, Hirano, Michio, Villarroya, Francesc
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246498/
https://ncbi.nlm.nih.gov/pubmed/22216345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029691
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