Protein Kinase C Delta (PKCδ) Affects Proliferation of Insulin-Secreting Cells by Promoting Nuclear Extrusion of the Cell Cycle Inhibitor p21(Cip1/WAF1)

BACKGROUND: High fat diet-induced hyperglycemia and palmitate-stimulated apoptosis was prevented by specific inhibition of protein kinase C delta (PKCδ) in β-cells. To understand the role of PKCδ in more detail the impact of changes in PKCδ activity on proliferation and survival of insulin-secreting...

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Hlavní autoři: Ranta, Felicia, Leveringhaus, Johannes, Theilig, Dorothea, Schulz-Raffelt, Gabriele, Hennige, Anita M., Hildebrand, Dominic G., Handrick, René, Jendrossek, Verena, Bosch, Fatima, Schulze-Osthoff, Klaus, Häring, Hans-Ulrich, Ullrich, Susanne
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246440/
https://ncbi.nlm.nih.gov/pubmed/22216119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028828
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