Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2

The meiosis-specific synaptonemal complex protein SYCP3 has been reported to be aberrantly expressed in tumours. However, in contrast to its well-defined function in meiosis, its possible role in mitotic cells is entirely unknown. Here, we show that SYCP3 is expressed in a range of primary tumours a...

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Bibliografiske detaljer
Main Authors: Hosoya, Noriko, Okajima, Miyuki, Kinomura, Aiko, Fujii, Yoshihiro, Hiyama, Takashi, Sun, Jiying, Tashiro, Satoshi, Miyagawa, Kiyoshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246250/
https://ncbi.nlm.nih.gov/pubmed/22116401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.221
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