Th17 cells are long-lived and retain a stem cell-like molecular signature

Th17 cells have been described as short-lived but this view is at odds with their capacity to trigger protracted damage to normal and transformed tissues. We report that Th17 cells, despite displaying low expression of CD27 and other phenotypic markers of terminal differentiation, efficiently eradic...

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Auteurs principaux: Muranski, Pawel, Borman, Zachary A., Kerkar, Sid P., Klebanoff, Christopher A., Ji, Yun, Sanchez-Perez, Luis, Sukumar, Madhusudhanan, Reger, Robert N., Yu, Zhiya, Kern, Steven J., Roychoudhuri, Rahul, Ferreyra, Gabriela A., Shen, Wei, Durum, Scott K., Feigenbaum, Lionel, Palmer, Douglas C., Antony, Paul A., Chan, Chi-Chao, Laurence, Arian, Danner, Robert L., Gattinoni, Luca, Restifo, Nicholas P.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246082/
https://ncbi.nlm.nih.gov/pubmed/22177921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.09.019
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