A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

How RING E3 ligases mediate E2-to-substrate ubiquitin-like protein (UBL) transfer remains unknown. Here we address how the RING E3 RBX1 positions NEDD8’s E2 (UBC12) and substrate (CUL1). We find that existing structures are incompatible with CUL1 NEDD8ylation and report a new conformation of RBX1 th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Calabrese, Matthew F., Scott, Daniel C., Duda, David M., Grace, Christy R.R., Kurinov, Igor, Kriwacki, Richard W., Schulman, Brenda A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245743/
https://ncbi.nlm.nih.gov/pubmed/21765416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2086
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