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Structural basis for promoter –10 element recognition by the bacterial RNA polymerase σ subunit

The key step in bacterial promoter opening is recognition of the -10 promoter element (T(-12)A(-11)T(-10)A(-9)A(-8)T(-7) consensus sequence) by the RNA polymerase σ subunit. We determined crystal structures of σ domain 2 bound to single-stranded DNA bearing -10 element sequences. Extensive interacti...

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Bibliografiske detaljer
Main Authors: Feklistov, Andrey, Darst, Seth A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245737/
https://ncbi.nlm.nih.gov/pubmed/22136875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.10.041
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