Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance

Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. The extent to which ALDH-2 contributes to GTN t...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Sydow, Karsten, Daiber, Andreas, Oelze, Matthias, Chen, Zhiqiang, August, Michael, Wendt, Maria, Ullrich, Volker, Mülsch, Alexander, Schulz, Eberhard, Keaney, John F., Stamler, Jonathan S., Münzel, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2004
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC324536/
https://ncbi.nlm.nih.gov/pubmed/14755345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419267
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky