Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance

Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. The extent to which ALDH-2 contributes to GTN t...

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Detalhes bibliográficos
Main Authors: Sydow, Karsten, Daiber, Andreas, Oelze, Matthias, Chen, Zhiqiang, August, Michael, Wendt, Maria, Ullrich, Volker, Mülsch, Alexander, Schulz, Eberhard, Keaney, John F., Stamler, Jonathan S., Münzel, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC324536/
https://ncbi.nlm.nih.gov/pubmed/14755345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419267
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