Mitochondrial oxidative stress and nitrate tolerance – comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD(+/- )mice

BACKGROUND: Chronic therapy with nitroglycerin (GTN) results in a rapid development of nitrate tolerance which is associated with an increased production of reactive oxygen species (ROS). According to recent studies, mitochondrial ROS formation and oxidative inactivation of the organic nitrate bioac...

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Detalhes bibliográficos
Main Authors: Mollnau, Hanke, Wenzel, Philip, Oelze, Matthias, Treiber, Nicolai, Pautz, Andrea, Schulz, Eberhard, Schuhmacher, Swenja, Reifenberg, Kurt, Stalleicken, Dirk, Scharffetter-Kochanek, Karin, Kleinert, Hartmut, Münzel, Thomas, Daiber, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1654181/
https://ncbi.nlm.nih.gov/pubmed/17092343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2261-6-44
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