Mitochondrial oxidative stress and nitrate tolerance – comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD(+/- )mice

BACKGROUND: Chronic therapy with nitroglycerin (GTN) results in a rapid development of nitrate tolerance which is associated with an increased production of reactive oxygen species (ROS). According to recent studies, mitochondrial ROS formation and oxidative inactivation of the organic nitrate bioac...

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Main Authors: Mollnau, Hanke, Wenzel, Philip, Oelze, Matthias, Treiber, Nicolai, Pautz, Andrea, Schulz, Eberhard, Schuhmacher, Swenja, Reifenberg, Kurt, Stalleicken, Dirk, Scharffetter-Kochanek, Karin, Kleinert, Hartmut, Münzel, Thomas, Daiber, Andreas
格式: Artigo
語言:Inglês
出版: BioMed Central 2006
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1654181/
https://ncbi.nlm.nih.gov/pubmed/17092343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2261-6-44
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