Mitochondrial oxidative stress and nitrate tolerance – comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD(+/- )mice

BACKGROUND: Chronic therapy with nitroglycerin (GTN) results in a rapid development of nitrate tolerance which is associated with an increased production of reactive oxygen species (ROS). According to recent studies, mitochondrial ROS formation and oxidative inactivation of the organic nitrate bioac...

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Bibliografische gegevens
Hoofdauteurs: Mollnau, Hanke, Wenzel, Philip, Oelze, Matthias, Treiber, Nicolai, Pautz, Andrea, Schulz, Eberhard, Schuhmacher, Swenja, Reifenberg, Kurt, Stalleicken, Dirk, Scharffetter-Kochanek, Karin, Kleinert, Hartmut, Münzel, Thomas, Daiber, Andreas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2006
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1654181/
https://ncbi.nlm.nih.gov/pubmed/17092343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2261-6-44
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