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Mitochondrial oxidative stress and nitrate tolerance – comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD(+/- )mice

BACKGROUND: Chronic therapy with nitroglycerin (GTN) results in a rapid development of nitrate tolerance which is associated with an increased production of reactive oxygen species (ROS). According to recent studies, mitochondrial ROS formation and oxidative inactivation of the organic nitrate bioac...

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Bibliografiske detaljer
Main Authors: Mollnau, Hanke, Wenzel, Philip, Oelze, Matthias, Treiber, Nicolai, Pautz, Andrea, Schulz, Eberhard, Schuhmacher, Swenja, Reifenberg, Kurt, Stalleicken, Dirk, Scharffetter-Kochanek, Karin, Kleinert, Hartmut, Münzel, Thomas, Daiber, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1654181/
https://ncbi.nlm.nih.gov/pubmed/17092343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2261-6-44
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