Vascular Dysfunction in Experimental Diabetes Is Improved by Pentaerithrityl Tetranitrate but Not Isosorbide-5-Mononitrate Therapy

OBJECTIVE: Diabetes is associated with vascular oxidative stress, activation of NADPH oxidase, and uncoupling of nitric oxide (NO) synthase (endothelial NO synthase [eNOS]). Pentaerithrityl tetranitrate (PETN) is an organic nitrate with potent antioxidant properties via induction of heme oxygenase-1...

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Main Authors: Schuhmacher, Swenja, Oelze, Matthias, Bollmann, Franziska, Kleinert, Hartmut, Otto, Christian, Heeren, Tjebo, Steven, Sebastian, Hausding, Michael, Knorr, Maike, Pautz, Andrea, Reifenberg, Kurt, Schulz, Eberhard, Gori, Tommaso, Wenzel, Philip, Münzel, Thomas, Daiber, Andreas
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2011
Assuntos:
Pharmacology and Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178293/
https://ncbi.nlm.nih.gov/pubmed/21844097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1395
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