Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

AIMS: Imbalance between pro- and antioxidant species (e.g. during aging) plays a crucial role for vascular function and is associated with oxidative gene regulation and modification. Vascular aging is associated with progressive deterioration of vascular homeostasis leading to reduced relaxation, hy...

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Hauptverfasser: Wenzel, Philip, Schuhmacher, Swenja, Kienhöfer, Joachim, Müller, Johanna, Hortmann, Marcus, Oelze, Matthias, Schulz, Eberhard, Treiber, Nicolai, Kawamoto, Toshihiro, Scharffetter-Kochanek, Karin, Münzel, Thomas, Bürkle, Alexander, Bachschmid, Markus Michael, Daiber, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2008
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937602/
https://ncbi.nlm.nih.gov/pubmed/18596060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvn182
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