Highly compacted DNA nanoparticles with low MW PEG coatings: in vitro, ex vivo and in vivo evaluation

Highly compacted DNA nanoparticles, composed of single molecules of plasmid DNA compacted with block copolymers of poly-L-lysine and 10 kDa polyethylene glycol (CK(30)PEG(10k)), mediate effective gene delivery to the brain, eyes and lungs in vivo. Nevertheless, we found that CK(30)PEG(10k) DNA nanop...

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Bibliografiske detaljer
Main Authors: Boylan, Nicholas J., Suk, Jung Soo, Lai, Samuel K., Jelinek, Raz, Boyle, Michael P., Cooper, Mark J., Hanes, Justin
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245330/
https://ncbi.nlm.nih.gov/pubmed/21903145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2011.08.031
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