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Lung Gene Therapy with Highly Compacted DNA Nanoparticles that Overcome the Mucus Barrier
Inhaled gene carriers must penetrate the highly viscoelastic and adhesive mucus barrier in the airway in order to overcome rapid mucociliary clearance and reach the underlying epithelium; however, even the most widely used viral gene carriers are unable to efficiently do so. We developed two polymer...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3951606/ https://ncbi.nlm.nih.gov/pubmed/24440664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.01.007 |
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