Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

Gene therapy has emerged as an alternative for the treatment of diseases refractory to conventional therapeutics. Synthetic nanoparticle-based gene delivery systems offer highly tunable platforms for the delivery of therapeutic genes. However, the inability to achieve sustained, high-level transgene...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Mastorakos, Panagiotis, da Silva, Adriana L., Chisholm, Jane, Song, Eric, Choi, Won Kyu, Boyle, Michael P., Morales, Marcelo M., Hanes, Justin, Suk, Jung Soo
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507234/
https://ncbi.nlm.nih.gov/pubmed/26124127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502281112
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