An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy

Diffusion of the viral vectors evaluated in inhaled gene therapy clinical trials to date are largely hindered within airway mucus, which limits their access to, and transduction of, the underlying airway epithelium prior to clearance from the lung. Here, we discovered that adeno-associated virus (AA...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Duncan, Gregg A., Kim, Namho, Colon-Cortes, Yanerys, Rodriguez, Jason, Mazur, Marina, Birket, Susan E., Rowe, Steven M., West, Natalie E., Livraghi-Butrico, Alessandra, Boucher, Richard C., Hanes, Justin, Aslanidi, George, Suk, Jung Soo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054694/
https://ncbi.nlm.nih.gov/pubmed/30038933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.03.006
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