An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy

Diffusion of the viral vectors evaluated in inhaled gene therapy clinical trials to date are largely hindered within airway mucus, which limits their access to, and transduction of, the underlying airway epithelium prior to clearance from the lung. Here, we discovered that adeno-associated virus (AA...

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Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Duncan, Gregg A., Kim, Namho, Colon-Cortes, Yanerys, Rodriguez, Jason, Mazur, Marina, Birket, Susan E., Rowe, Steven M., West, Natalie E., Livraghi-Butrico, Alessandra, Boucher, Richard C., Hanes, Justin, Aslanidi, George, Suk, Jung Soo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054694/
https://ncbi.nlm.nih.gov/pubmed/30038933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.03.006
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