Combinatorial Binding in Human and Mouse Embryonic Stem Cells Identifies Conserved Enhancers Active in Early Embryonic Development

Transcription factors are proteins that regulate gene expression by binding to cis-regulatory sequences such as promoters and enhancers. In embryonic stem (ES) cells, binding of the transcription factors OCT4, SOX2 and NANOG is essential to maintain the capacity of the cells to differentiate into an...

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Detalhes bibliográficos
Main Authors: Göke, Jonathan, Jung, Marc, Behrens, Sarah, Chavez, Lukas, O'Keeffe, Sean, Timmermann, Bernd, Lehrach, Hans, Adjaye, James, Vingron, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245296/
https://ncbi.nlm.nih.gov/pubmed/22215994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002304
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