DNA–Methylome Analysis of Mouse Intestinal Adenoma Identifies a Tumour-Specific Signature That Is Partly Conserved in Human Colon Cancer

Aberrant CpG methylation is a universal epigenetic trait of cancer cell genomes. However, human cancer samples or cell lines preclude the investigation of epigenetic changes occurring early during tumour development. Here, we have used MeDIP-seq to analyse the DNA methylome of APC(Min) adenoma as a...

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Autori principali: Grimm, Christina, Chavez, Lukas, Vilardell, Mireia, Farrall, Alexandra L., Tierling, Sascha, Böhm, Julia W., Grote, Phillip, Lienhard, Matthias, Dietrich, Jörn, Timmermann, Bernd, Walter, Jörn, Schweiger, Michal R., Lehrach, Hans, Herwig, Ralf, Herrmann, Bernhard G., Morkel, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567140/
https://ncbi.nlm.nih.gov/pubmed/23408899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003250
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