ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

The associations of mutations in the enhancer of trithorax and polycomb family gene ASXL1 with pretreatment patient characteristics, outcomes, and gene-/microRNA-expression profiles in primary cytogenetically normal acute myeloid leukemia (CN-AML) are unknown. We analyzed 423 adult patients for ASXL...

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Detalhes bibliográficos
Main Authors: Metzeler, Klaus H., Becker, Heiko, Maharry, Kati, Radmacher, Michael D., Kohlschmidt, Jessica, Mrózek, Krzysztof, Nicolet, Deedra, Whitman, Susan P., Wu, Yue-Zhong, Schwind, Sebastian, Powell, Bayard L., Carter, Thomas H., Wetzler, Meir, Moore, Joseph O., Kolitz, Jonathan E., Baer, Maria R., Carroll, Andrew J., Larson, Richard A., Caligiuri, Michael A., Marcucci, Guido, Bloomfield, Clara D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245212/
https://ncbi.nlm.nih.gov/pubmed/22031865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-368225
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