mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells

Increased mast cell burden is observed in the inflamed tissues and affected organs and tissues of patients with mast cell proliferative disorders. However, normal mast cells participate in host defense, so approaches to preferentially target clonally expanding mast cells are needed. We found that ma...

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Autors principals: Smrž, Daniel, Kim, Mi-Sun, Zhang, Shuling, Mock, Beverly A., Smržová, Šárka, DuBois, Wendy, Simakova, Olga, Maric, Irina, Wilson, Todd M., Metcalfe, Dean D., Gilfillan, Alasdair M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245204/
https://ncbi.nlm.nih.gov/pubmed/22053105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-359984
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