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Quantifying Prefibrillar Amyloids in vitro by Using a “Thioflavin-Like” Spectroscopic Method

In Alzheimer’s disease (AD) and other neurodegenerative disorders, proteins accumulate into ordered aggregates, called amyloids. Recent evidence suggests that these structures include both large, insoluble fibrils and smaller, prefibrillar structures, such as dimers, oligomers, and protofibrils. Rec...

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Bibliografiske detaljer
Main Authors: Reinke, Ashley A., Abulwerdi, Gelareh A., Gestwicki, Jason E.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244937/
https://ncbi.nlm.nih.gov/pubmed/20677203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201000358
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