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Quantifying Prefibrillar Amyloids in vitro by Using a “Thioflavin-Like” Spectroscopic Method

In Alzheimer’s disease (AD) and other neurodegenerative disorders, proteins accumulate into ordered aggregates, called amyloids. Recent evidence suggests that these structures include both large, insoluble fibrils and smaller, prefibrillar structures, such as dimers, oligomers, and protofibrils. Rec...

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Detalhes bibliográficos
Main Authors: Reinke, Ashley A., Abulwerdi, Gelareh A., Gestwicki, Jason E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244937/
https://ncbi.nlm.nih.gov/pubmed/20677203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201000358
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