Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17)

BACKGROUND: Peripheral serotonin (5-hydroxytryptamine, 5-HT) is transported by platelets and released upon stimulation. In the platelet cytoplasm, 5-HT is transamidated to small GTPases, promoting α-granule release and primary hemostasis. OBJECTIVE: We hypothesized that 5-HT could also stimulate pla...

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Bibliographic Details
Main Authors: Duerschmied, D., Canault, M., Lievens, D., Brill, A., Cifuni, S. M., Bader, M., Wagner, D. D.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244876/
https://ncbi.nlm.nih.gov/pubmed/19426283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2009.03476.x
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