Microparticles of Human Atherosclerotic Plaques Enhance the Shedding of the Tumor Necrosis Factor-α Converting Enzyme/ADAM17 Substrates, Tumor Necrosis Factor and Tumor Necrosis Factor Receptor-1

Human atherosclerotic plaques express the metalloprotease tumor necrosis factor (TNF)-α converting enzyme (TACE/ADAM-17), which cleaves several transmembrane proteins including TNF and its receptors (TNFR-1 and TNFR-2). Plaques also harbor submicron vesicles (microparticles, MPs) released from plasm...

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Autores principales: Canault, Matthias, Leroyer, Aurélie S., Peiretti, Franck, Lesèche, Guy, Tedgui, Alain, Bonardo, Bernadette, Alessi, Marie-Christine, Boulanger, Chantal M., Nalbone, Gilles
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2007
Materias:
Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043531/
https://ncbi.nlm.nih.gov/pubmed/17872973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070021
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