Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion

AIMS: Oxidative stress accompanies inflammatory and vascular diseases. The objective of this study was to explore whether reactive oxygen species can activate shedding of platelet receptors and thus suppress platelet function. METHODS AND RESULTS: Hydrogen peroxide and glucose oxidase were chosen to...

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Main Authors: Brill, Alexander, Chauhan, Anil K., Canault, Matthias, Walsh, Meghan T., Bergmeier, Wolfgang, Wagner, Denisa D.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2009
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741344/
https://ncbi.nlm.nih.gov/pubmed/19482949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp176
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