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Modulation of TCRβ Surface Expression During TCR Revision

TCR revision is a tolerance mechanism by which self-reactive TCRs expressed by mature CD4(+) peripheral T cells are replaced by receptors encoded by genes generated by post-thymic DNA rearrangement. The down modulation of surface TCR expression initiates TCR revision, and serves as a likely trigger...

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Detalhes bibliográficos
Main Authors: Simmons, Kalynn B., Wubeshet, Maramawit, Ames, Kristina T., McMahan, Catherine J., Hale, J. Scott, Fink, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244515/
https://ncbi.nlm.nih.gov/pubmed/22138498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2011.10.022
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