Activation of mitochondrial u-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion

Ubiquitous calpains (calpain I & II) are generally recognized as cytosolic proteins. Recently, mitochondrial localized calpain I (μ-calpain) has been identified. Activation of mito-u-calpain cleaves apoptosis inducing factor (AIF), a flavoprotein located within the mitochondrial intermembrane sp...

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Hlavní autoři: Chen, Qun, Paillard, Melanie, Gomez, Ludovic, Ross, Thomas, Hu, Ying, Xu, Aijun, Lesnefsky, Edward J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244491/
https://ncbi.nlm.nih.gov/pubmed/22057010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.10.037
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