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Synthesis of the C21–C34 fragment of antascomicin B

The C21–C34 fragment of the potent FKBP12-binding macrolide antascomicin B was prepared using Ireland-Claisen and allylic diazene rearrangements to establish the C26/C27 and the C23 stereocenters, respectively. Directed hydrogenation installed the C29 β-configuration. The fragment possesses 7 of the...

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Autors principals: Hutchison, John M., Gibson, Andrew S., Williams, David T., McIntosh, Matthias C.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244276/
https://ncbi.nlm.nih.gov/pubmed/22199407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2011.09.027
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