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The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR

Caenorhabditis elegans let-7, a founding member of the microRNA family, is predicted to bind to six sites in the 3′UTR of the mRNA of its target gene, lin-41, to down-regulate LIN-41. Here, we demonstrate that wild-type let-7 microRNA binds in vitro to RNA from the lin-41 3′UTR. This interaction is...

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Auteurs principaux: Vella, Monica C., Choi, Eun-Young, Lin, Shin-Yi, Reinert, Kristy, Slack, Frank J.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2004
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC324419/
https://ncbi.nlm.nih.gov/pubmed/14729570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1165404
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