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The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR
Caenorhabditis elegans let-7, a founding member of the microRNA family, is predicted to bind to six sites in the 3′UTR of the mRNA of its target gene, lin-41, to down-regulate LIN-41. Here, we demonstrate that wild-type let-7 microRNA binds in vitro to RNA from the lin-41 3′UTR. This interaction is...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC324419/ https://ncbi.nlm.nih.gov/pubmed/14729570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1165404 |
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