MOLECULAR MECHANISM OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) INACTIVATION BY α,β-UNSATURATED CARBONYL DERIVATIVES

α,β-Unsaturated carbonyls are an important class of chemicals involved in environmental toxicity and disease processes. Whereas adduction of cysteine residues on proteins is a well-documented reaction of these chemicals, such a generic effect cannot explain the molecular mechanism of cytotoxicity. I...

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Bibliographic Details
Main Authors: Martyniuk, Christopher J., Fang, Bin, Koomen, John M., Gavin, Terrence, Zhang, Lihai, Barber, David S., LoPachin, Richard M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243798/
https://ncbi.nlm.nih.gov/pubmed/22084934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200437y
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