Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3

TGF-β signalling is regulated by post-translational modifications of Smad proteins to translate quantitative difference in ligand concentration into proportional transcriptional output. Previous studies in cell culture systems suggested that Smad ubiquitination regulatory factors (Smurfs) act in thi...

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Hlavní autoři: Tang, Liu-Ya, Yamashita, Motozo, Coussens, Nathan P, Tang, Yi, Wang, Xiangchun, Li, Cuiling, Deng, Chu-Xia, Cheng, Steven Y, Zhang, Ying E
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243605/
https://ncbi.nlm.nih.gov/pubmed/22045334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.393
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